MG has received lecture fees from Menarini, RGM has no conflict of interest
One of the ongoing debates about this entire class of medications is whether the effects are mediated solely by weight loss and mitigation of the inflammatory consequences of energy toxicity (read: too many calories) versus other biological effects of these medications
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10.1248/bpb.31.1469 47 HaradaM.TadevosyanA.QiX.XiaoJ.LiuT.VoigtN.et al (2015)
In contrast, the concordance of benchmarking results for all outcomes, including mortality, in the SURPASS-CVOT emulation study comparing tirzepatide to dulaglutide provided support for the validity of evaluating these outcomes in expanded study populations